Angélica Vargas
Docente
Universidad Sergio Arboleda
Biologists often represent
genetic interactions by means of graphs. In these genetic regulatory
graphs, vertices represent genes or their regulatory products,
whereas edges are directed and represent regulatory effects from one gene
on another. Edges are often labelled with a sign, positive (+1) in the
case of an activation and negative (−1) for an inhibition. The
biologist R. Thomas has enounced a rule relating multistationarity in a system
of genes interacting in a single cell to the existence of a positive
circuit in the regulatory graph of the system.
Multistability corresponds
to important biological phenomena, namely cell differentiation processes.
